Derivation of human-derived iPSC line from a male adolescent with first-episode of sporadic schizophrenia.

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Tác giả: Youhui Jiang, Tao Li, Peiyan Ni, Xinyi Ren, Qiang Wang, Jun Zhao, Chuqing Zhou

Ngôn ngữ: eng

Ký hiệu phân loại: 629.28304 Motor land vehicles, cycles

Thông tin xuất bản: England : Stem cell research , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 707956

Schizophrenia is considered to be a neurodevelopmental disorder with high heritability. In this study, peripheral blood mononuclear cells (PBMCs) were collected from a male adolescent diagnosed with first-episode of sporadic schizophrenia. Induced pluripotent stem cells (iPSCs) were generated by reprogramming using the factors OCT4, SOX2, NANOG, LIN28, c-MYC, KLF4, and SV40LT. The generated iPSC line was validated by karyotype analysis and expression of pluripotency markers. These iPSCs were capable of differentiating into derivatives of all three germ layers in vivo.
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