Many Mexican American immigrant families live in socioeconomically disadvantaged neighborhoods, which are recognized as risk factors influencing residents' stress. However, how neighborhood contexts can impact physiological stress at the family level, as indicated by hair cortisol concentration (HCC), particularly among Mexican immigrant family members remains unclear. Using a person-centered approach, the current study identified distinct patterns of family-level HCC and examined their associations with neighborhood contexts (i.e., Hispanic/immigrant concentration, socioeconomic disadvantage, affluence). Participants included 398 adolescents (56.5 % female, M