Toxic effects of combined exposure to carbamazepine and triclosan on adult zebrafish (Danio rerio): Insights into acute mortality, neurotransmitters, biochemical response, and histopathology.

• Tác giả: Yanhong Chang, Xinxin Du, Huixue Duan, Xinjie Guo, Xing Hu, Jiangong Jiang, Rongyu Li, Wenzhen Liu, Haiyang Yu, Shuxin Zhao, Xinyuan Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 354.59 *Commodity programs
• Thông tin xuất bản: United States : Comparative biochemistry and physiology. Toxicology & pharmacology : CBP , 2025
• Bộ sưu tập: NCBI
• ID: 708369

Tóm tắt

As two representative pharmaceuticals and personal care products (PCPPs), carbamazepine (CBZ) and triclosan (TCS) are frequently detected in aquatic ecosystems worldwide, but their toxicological interactions remain unclear. This work evaluated the combined toxicity of CBZ and TCS to zebrafish (Danio rerio) in terms of acute mortality, biochemical response, and histopathology. The results showed that the 96-h acute toxicity interaction of CBZ and TCS fitted well to the concentration addition (CA) model, suggesting an additive effect. Compared with exposure to either CBZ or TCS alone, co-exposure to CBZ and TCS at equivalent toxic concentrations can lead to a profound increase in gamma-aminobutyric acid (GABA) and a reduction in acetylcholine (ACh) and acetylcholinesterase (AChE) levels. Compared with CBZ or TCS alone, the 21-day co-exposure to CBZ and TCS at the 2 % LC