Salcastaniols A-G, seven undescribed diterpenoids with cholinesterase inhibitory activities from Salvia castanea Diels f. tomentosa Stib.

• Tác giả: Min Chen, Zhaoyue Dong, Feng Ju, Zhihua Liao, Qingju Liu, Fancheng Meng, Mohammad Mahmoud Nagdy, Miaomiao Sun, Guowei Wang, Pingping Wang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 787.73 *Frame, ground, harp, raft zithers
• Thông tin xuất bản: England : Phytochemistry , 2025
• Bộ sưu tập: NCBI
• ID: 708388

Tóm tắt

Salcastaniols A-G (1-7), seven undescribed diterpenoids, together with 29 known ones, were isolated from Salvia castanea Diels f. tomentosa Stib. Their structures, including absolute configurations, were elucidated by NMR spectroscopy analysis, ECD experiments and quantum chemical calculation. The in vitro cholinesterase inhibitory activities of all isolates were evaluated using modified Ellman's method. Ten compounds exhibited AChE inhibitory activities with IC