Acute hypoxia induces sleep disorders via sima/HIF-1α regulation of circadian rhythms in adult Drosophila.

• Tác giả: Jianzheng He, Xiaolin Jiang, Shuwei Wang, Minghui Xiu, Dan Yang, Shihong Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Comparative biochemistry and physiology. Toxicology & pharmacology : CBP , 2025
• Bộ sưu tập: NCBI
• ID: 708405

Tóm tắt

The atmospheric oxygen concentration is significantly reduced in highland regions compared to lowland areas. The first entering the plateau can induce sleep disorders in individuals, primarily attributed to insufficient oxygen supply. This study used Drosophila melanogaster as a model organism to better understand the molecular mechanism of acute hypoxia-induced sleep disorders. The Drosophila activity monitoring system (DAMS) was employed to observe the sleep-wake in adult (w