Dl-3-n-Butylphthalide enhances the survival of rat bone marrow stem cells via a reactive oxygen species mediated Erk1/2 signaling pathway.

• Tác giả: Shikun Cai, Xianjin Ke, Ting Lu, Bo Sun, Zhenjie Sun, Xiangyang Tian, Bingjian Wang, Chengyun Wang, Qianqian Wu, Xian Wu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 630.2 Miscellany and scientific principles
• Thông tin xuất bản: Netherlands : Brain research , 2025
• Bộ sưu tập: NCBI
• ID: 708505

Tóm tắt

Survival of bone marrow stem cells (BMSCs) is crucial for successful bone marrow transplantation. However, the underlying molecular mechanisms remain inadequately understood. Our previous research has demonstrated that dl-3-n-butylphthalide (NBP) can protect rat BMSCs from cell death via its antioxidative properties and by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. The findings suggest that the PI3K/Akt pathway may be one of the primary targets through which NBP exert its protective effects. In this study, we explored an additional signaling pathway to further elucidate the molecular mechanisms involved in NBP-mediated protection against oxidative stress injury in rat BMSCs (rBMSCs). Oxidative stress was induced in rBMSCs using hydrogen peroxide (H