Lung resistance - but not compliance - impairs P0.1 and maximal inspiratory pressure measurements.

• Tác giả: Florian Blanchard, Jean-Michel Constantin, Hind Hani, Mathieu Koszutski, Mickael Lescroart, Bruno Levy, Benjamin Pequignot, Alma Revol, Mathieu Specklin
• Ngôn ngữ: eng
• Thông tin xuất bản: France : Anaesthesia, critical care & pain medicine , 2025
• Bộ sưu tập: NCBI
• ID: 708508

Tóm tắt

INTRODUCTION: Bedside tools have been developed to assess inspiratory muscle function and inspiratory drive for patients under invasive mechanical ventilation. Occlusion maneuvers are currently considered but their pitfalls remain underexplored. We aimed to assess the impact of respiratory system compliance and resistance on P0.1 (addressing respiratory drive and inspiratory muscle function) and maximal inspiratory pressure (MIP, assessing global inspiratory muscle function) monitoring for fixed inspiratory muscle pressure (P METHODS: The Active Servo Lung 5000 (ASL-5000) was used to reproduce respiratory conditions under fixed P RESULTS: Resistance challenge impacted the monitoring of both P0.1 and MIP while compliance challenge barely modified P0.1 and MIP under all P DISCUSSION: Lung Resistance - but not Compliance - impairs P0.1 and Maximal Inspiratory Pressure Measurements. Further clinical studies are mandatory to define pitfalls and limits of occlusion maneuver monitoring.