Development and evaluation of biphenyl-based small-molecule radiotracers for PET imaging of PD-L1 in tumor.

• Tác giả: Shuyue Cai, Xin Hu, Jianguo Lin, Gaochao Lv, Ling Qiu, Qianhui Wang, Quan Xie, Nan Zhang, Yuxuan Zhou, Junyi Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 658.32259 Personnel management (Human resource management)
• Thông tin xuất bản: England : Bioorganic & medicinal chemistry letters , 2025
• Bộ sưu tập: NCBI
• ID: 708594

Tóm tắt

Accurate identification of programmed cell death ligand 1 (PD-L1) expression is crucial for anti-tumor immunotherapy. However, the heterogeneity of PD-L1 expression in tumors makes it challenging to detect by immunohistochemistry. In this study, we developed two novel PD-L1 small-molecule PET tracers, [