As the medical field develops rapidly towards evidence-based, personalized and intelligent care, patient-reported outcomes (PRO) related research is becoming increasingly refined in terms of coverage, precision and practicability. In order to help improve the quality and quantity of patient-centered evidence in dentistry and to further promote the wide and standard use of dental patient-reported outcomes (dPROs) and dental patient-reported outcome measures (dPROMs), the Journal of Evidence-Based Dental Practice has put together this Special Issue, the fourth of a series entitled Dental Patient-Reported Outcomes Update. A total of 7 solicited articles are included in this issue. To put them into a broader perspective, this review provides a concise summary of key, selected PRO and dPRO articles published during 2024. A brief introduction to those articles included in this Special Issue follows. Four main domains are covered in this Special Issue: (i) dPROs and general health, (ii) standardization of dPRO-related methodology, (iii) methodological considerations in dPRO-related research, and (iv) current usage of dPROs and dPROMs in published research.