Early manifestations of large-vessel vasculitis are often non-specific, which can result in missed or delayed diagnosis. A case of Takayasu arteritis with femoral artery predominance diagnosed using fluorodeoxyglucose-positron emission tomography/CT (FDG-PET/CT) imaging in a patient with fevers, myalgia, lower limb claudication and erectile pain is presented in this report. This case report describes an unusual genitourinary manifestation of vasculitis and highlights the utility of FDG-PET/CT in the diagnostic work-up of patients with fever of unknown origin.