Due to a large number of nosocomial, but also hospital-associated infections, sepsis and therefore septic shock occur frequently in everyday clinical practice. Considering the high prevalence and mortality rate of the disease and its complexity, precise knowledge of pathophysiology, diagnostics and therapy is essential for every clinical doctor.Because time in this case is such a critical factor, patients in septic shock in particular require a standardized approach and targeted, swift diagnostics to start adequate treatment as soon as possible. In addition to hemodynamic stabilization, the treatment of the infection's origin is particularly important.This article is intended to provide an overview of the most important diagnostic tools, treatment strategies and concepts, as well as practical assistance for everyday clinical practice.