Compared to males, aggression is less frequently noticed in females. Fierce maternal-aggression to thwart the attack/threat of male-conspecific/intruder is transiently expressed as she defends her pups. The odor cues emanated by the intruder provoke aggressive behavior by robustly activating the ventral-premammillary nucleus (PMv) in the hypothalamic-attack area (HAA). But, how PMv activation triggers aggression is unclear. In view of neuropeptide CART's potential to reconfigure neural circuits for behavioral demands, occurrence throughout aggression-circuitry, and abundance particularly in PMv, we test the role of PMv