Alpha-fetoprotein (AFP) is reduced at 36 weeks' gestation in pregnancies destined to deliver small for gestational age infants.

• Tác giả: Lucy A Bartho, Ping Cannon, Natalie J Hannan, Tu'uhevaha J Kaitu'u-Lino, Manju Kandel, Teresa M MacDonald, Joshua Masci, Tuong-Vi Nguyen, Susan P Walker, Georgia P Wong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 946.7 *Eastern Spain and Andorra
• Thông tin xuất bản: Ireland : European journal of obstetrics, gynecology, and reproductive biology , 2025
• Bộ sưu tập: NCBI
• ID: 708826

Tóm tắt

 Alpha-fetoprotein (AFP) is a protein commonly used to screen for aneuploidy in pregnancy. This study measured circulating AFP in maternal plasma at 36 weeks' gestation preceding diagnosis of term preeclampsia or delivery of a small for gestational age infant (SGA
  <
 10 % birthweight centile) in a case-cohort design (122 SGA
  23 preeclampsia
  182 controls). AFP was significantly reduced in SGA <
  5th birthweight centile (n = 51
  P = 0.002) but not changed preceding preeclampsia diagnosis. This suggests that AFP is reduced near term preceding SGA diagnosis and may have potential as a biomarker if combined with other candidate molecules.