Small intestine-residing probiotics suppress neurotoxic bile acid production via extracellular vesicle-mediated inhibition of Clostridium scindens.

• Tác giả: Wei-Leng Chin, Chih-Yao Hou, Qiao-Yu Hsu, Wei-Hsuan Hsu, Bao-Hong Lee, Chi-Wei Lin, Ming-Chyi Pai
• Ngôn ngữ: eng
• Ký hiệu phân loại: 631.83 Potassium fertilizers
• Thông tin xuất bản: Canada : Food research international (Ottawa, Ont.) , 2025
• Bộ sưu tập: NCBI
• ID: 708898

Tóm tắt

Dysbiosis in gut microbiota and abnormalities in bile acids have been linked to neurodegenerative diseases. While many studies have focused on the relationship between colonic bacteria and Alzheimer's disease (AD), this study propose that alterations in the small intestine microbiota may play a more critical role. This is because the small intestine is pivotal in recycling bile acids through enterohepatic circulation. This study uses amyloid precursor protein knock-in (APP