INTRODUCTION: The objective of this study was to assess the calcium ions (Ca METHODS: ES (n = 10) and ESF (n = 10) forms were tested for their bioactivity. Elemental analysis was done on the fresh material and material immersed in phosphate-buffered saline (PBS) for 30 days. The surface crystal formation was studied. Cytotoxicity was evaluated at different material concentrations using a human hepatocellular cancer cell line (Huh-7). RESULTS: Both materials contain Ca, P, Ta, Zr, and Si as major elements. Both ES and ESF have a limited percentage of ytterbium and neodymium. In the fresh material, compared with the ESF, the ES had a higher Ca CONCLUSIONS: When ES and ESF were submerged in simulated bodily fluid, both forms produced apatite crystals at the dentin material interface, releasing high Ca