AIM: This study examines the mediating role of attitude towards preventing pressure injuries (PIs) in the effect of knowledge about Medical Device-Related Pressure Injuries (MDRPI) on self-efficacy in PI management among Turkish intensive care unit (ICU) nurses. MATERIALS AND METHODS: A descriptive, cross-sectional study was conducted with 302 ICU nurses in Turkey from October 15, 2023, to April 30, 2024. Data were collected using the Nurse Information Form, Medical Device Related Pressure Injury Knowledge Assessment Test (MDRPI-KAT), Attitude towards Pressure Ulcer Prevention Instrument (APuP), and the Pressure Ulcer Management Self-Efficiency Scale (PUMSES). RESULTS: ICU nurses had a knowledge score of 9.20 ± 2.32, with a correct response rate of 57.5 %. Their attitude score was 42.41 ± 5.46, with 76.5 % showing a satisfactory attitude (≥75 %). The self-efficacy score for PI management was 60.59 ± 21.03. Knowledge level positively and significantly affected attitude (B = 0.963, 95 % CI [0.720-1.206]), and attitude positively and significantly affected self-efficacy (B = 0.837, 95 % CI [0.370-1.304]). The direct effect of knowledge on PI management self-efficacy was non-significant without a mediator (B = 0.339
p = 0.542
95 % CI [-0.756-1.435]), but the indirect effect through attitude was significant (B = 0.806
95 % CI [0.289-1.399]). CONCLUSION: The study found that Turkish ICU nurses' knowledge of MDRPIs was below desired levels, though their self-efficacy was slightly above average and their attitudes were satisfactory. Attitude fully mediated the relationship between knowledge and self-efficacy, suggesting that enhancing nurses' knowledge and attitudes can improve their self-efficacy in managing PIs.