AIM: The aim of this study was to determine nursing students' levels of knowledge and attitudes regarding medical device-related pressure injuries (MDRPIs), as well as the factors influencing these. MATERIALS AND METHODS: This descriptive and cross-sectional study was conducted with 581 nursing students between January and May 2024. Data were collected using the Student Information Form, the Medical Device Related Pressure Injury Knowledge Assessment Test (MDRPI-KAT), and the Medical Device Related Pressure Injury Attitude Questionnaire (MDRPI-AQ). RESULTS: The nursing students had a mean score of 8.76 ± 2.68 on the MDRPI-KAT, indicating an overall correct answer percentage of 54.7 %. The mean total score on the MDRPI-AQ was 44.08 ± 8.12. Furthermore, 75.0 % of the nursing students (n = 436) achieved a positive attitude score (>
40 points). According to the results of the structural equation model, the scores on the MDRPI-KAT among nursing students had a statistically significant effect on their scores on the MDRPI-AQ (β = 0.585, p = 0.002). CONCLUSION: This study found that the nursing students exhibited insufficient knowledge about MDRPIs.Despite this, the nursing students demonstrated a positive attitude toward MDRPIs.