The structural integrity of the lips is essential for both aesthetic appeal and oral functionality. Defects in this region, which may arise from a variety of causes, can significantly affect a patient's physical and psychological well-being. This case report introduces a novel surgical technique designed for the repair of substantial defects in the lower lip. The procedure utilizes a nasolabial flap in conjunction with the facial artery myomucous flap. This innovative approach addresses considerable lip-related defect challenges effectively. The report delineates the surgical steps implemented and highlights the successful reconstruction of the lower lip. Following the surgery, the patient demonstrated a positive recovery trajectory, marked by significant improvements in both lip symmetry and functionality, with no notable complications. The integration of the nasolabial flap with the mucous membrane has proven effective in the repair of extensive lip defects, particularly in the skin and mucous membrane areas adjacent to the corners of the mouth. This procedure not only facilitates the restoration of appearance and function but also reduces the risk of further surgical trauma. Additionally, the report underscores the necessity of thorough preoperative planning to mitigate complications at the donor site.