Risk reducing mastectomy in Norwegian BRCA1/2 carriers.

• Tác giả: Eli Marie Grindedal, Hanne Kjensli Hyldebrandt, Lovise Mæhle, Ellen Schlichting, Astrid Tenden Stormorken, Valeria Vitelli
• Ngôn ngữ: eng
• Thông tin xuất bản: England : European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology , 2025
• Bộ sưu tập: NCBI
• ID: 709629

Tóm tắt

 BACKGROUND: Risk reducing mastectomy (RRM) is an option for women with pathogenic germline variants in BRCA1 or BRCA2 (BRCA1/2). This study investigates and compares RRM-uptake among Norwegian BRCA1/2 carriers from 2008 to 2021, temporal trends, and incidence of breast cancer (BC) after surgery. METHODS: BRCA1/2 carriers without prior breast or ovarian cancer, tested at Oslo University Hospital between January 1st RESULTS: In total, 1237 BRCA1/2 carriers were included, 679 (54.9 %) BRCA1 and 558 (45.1 %) BRCA2. Six hundred and four (48.8 %) had chosen RRM, 370 (54.5 %) BRCA1 and 234 (42.0 %) BRCA2 (p <
  0.001). Mean age at RRM was 40.1 for BRCA1 and 44.6 for BRCA2 (p <
  0.001). Mean time from GT to RRM was 2.3 years for BRCA1 and 3 years for BRCA2 (p <
  0.001). Women tested in 2015/2016 were 2.6 times more likely to choose RRM compared to those tested in 2008/2009. Two out of the 604 (0.3 %) had developed BC post-RRM. CONCLUSION: Nearly half of BRCA1/2 carriers had chosen RRM, with increasing uptake since 2008. Compared to BRCA2 carriers, more BRCA1 carriers chose RRM, were operated at a younger age and sooner after GT. Post-RRM BC incidence was low.