Chicken surfactant protein A1 activates macrophages phagocytosis and attenuates LPS-induced inflammatory response through the TLR4-mediated NF-кB pathway.

• Tác giả: Xinyuan Chen, Hongmei Liu, Chenxiao Wang, Hanwen Wu, Haifeng Xiong, Qian Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 667.2 Dyes and pigments
• Thông tin xuất bản: England : Poultry science , 2025
• Bộ sưu tập: NCBI
• ID: 709754

Tóm tắt

Chicken surfactant protein A1 (cSP-A1) is a soluble C-type lectin found primarily in chicken lungs. Its function and other potential bioactivities are unclear. This study aimed to express, purify, and identify recombinant cSP-A1 (RcSP-A1), investigate its effects on chicken macrophage HD11 cells, and evaluate its ability to regulate the LPS-induced inflammatory response. The results showed that RcSP-A1 was produced in HEK 293F cells and could be purified using a Ni