Polysaccharide Storage Myopathy.

• Tác giả: Anna M Firshman, Stephanie J Valberg
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : The Veterinary clinics of North America. Equine practice , 2025
• Bộ sưu tập: NCBI
• ID: 709851

Tóm tắt

Type 1 Polysaccharide Storage Myopathy (PSSM1) is an autosomal dominant glycogen storage disorder affecting more than 20 breeds of horses that can present with a variety of signs, including exertional rhabdomyolysis (ER). It is diagnosed by genetic testing or muscle biopsies containing muscle fibers with abnormal amylase-resistant polysaccharide. Type 2 PSSM has recently been subdivided. PSSM2-ER is a glycogen storage disorder identified in Quarter Horses that causes ER and is diagnosed by muscle biopsy as its genetic basis is unknown. Both PSSM1 and PSSM2-ER respond well to a low nonstructural carbohydrate, high fat diet combined with regular exercise. These forms of PSSM are discussed in this article.