DNA tetrahedron nanomedicine for enhanced antitumor and antimetastatic effect through the amplification of mitochondrial oxidative stress.

• Tác giả: Zixuan Chen, Songqin Liu, Zhaoyan Tian, Yafeng Wu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: England : Acta biomaterialia , 2025
• Bộ sưu tập: NCBI
• ID: 710133

Tóm tắt

Amplifying mitochondrial oxidative stress by elevating reactive oxygen species (ROS) and reducing glutathione (GSH) levels proved highly effective in eradicating tumor cells and inhibiting metastasis. How to significantly amplify mitochondrial oxidative stress remains a challenge due to the hypoxic microenvironment and high level of GSH in the mitochondria. Herein, we smartly fabricated a multifunctional DNA tetrahedron nanomedicine (tDNA-TPP-AuNCs-BPQDs) for intracellular enzyme activated fluorescence imaging and amplified mitochondrial oxidative stress. The apurinic/apyrimidinic site (AP site) on the cantilever of DNA tetrahedron (tDNA) could be rapidly cleaved by apurinic/apyrimidinic endonuclease 1 (APE1), allowing for in situ fluorescence imaging of APE1 with high sensitivity and specificity. Gold nanoclusters (AuNCs) could continuously convert intracellular H