This study aimed to investigate the effects of dietary fluoride (F) and curcumin (Cur) supplementation on the tibial biomechanical performance, histopathology, and behavior of pullets. Four dietary F levels (0, 400, 800, 1200 mg/kg) supplemented with CUR (0, 200 mg/kg) were used to create 8 experimental groups in Hyline Brown pullets. Behavioral study results showed that supplements of 1200 mg/kg F reduced the percentages of feeding, walking, standing, and preening behaviors while increasing the percentage of lying behavior (P <
0.05). This is associated with F-induced tibial elastic modulus, maximum stress, and stiffness coefficient were reduced and toughness coefficient was increased (P <
0.05). F-induced tibial cortical bone thickened, trabecular bone widened, and excessive accumulation of bone collagen fibers (P <
0.05) in the tibia explained the biomechanical properties reduction in Hyline Brown pullets. Additionally, the loss of antioxidant capacity was mediated by excessive F-accelerated pathological damage to the bone (P <
0.05). Supplementation with 200 mg/kg CUR alleviated abnormal behavior, expansion of the trabecular bone, accumulation of collagen fibers, and loss of antioxidant capacity (P <
0.05). In conclusion, F reduced the antioxidant level of the body, caused tibia histopathological damage, destroyed the tibia biomechanical properties, and caused abnormal behavior of pullets. Supplementation with 200 mg/kg CUR attenuates F-induced oxidative and tibia damage and rectifies abnormal behavioral traits.