The heavy metals (HMs) pollution caused by accelerated urbanization poses a significant risk to environmental and human health. Sediments, as an important component of aquatic ecosystems, have become a global environmental problem due to their HMs pollution. In this paper, 53 surface water and sediment samples were carried out in the industrial city of Changzhou to analyze and evaluate the pollution characteristics. A comprehensive source risk source allocation and source health risk integrated method based on positive matrix factorization (PMF) and health risk assessment models is applied. We found that the average concentration of most HMs accumulated in sediments greatly exceeds the soil background value in Changzhou, posing a high ecological risk. Pollution sources contribution to the HMs contents ranked as: electronic industry and mechanical manufacturing (29.18 %) >
metal smelting industry (20.97 %) >
atmospheric deposition and transportation (20.07 %) >
natural source (16.32 %) >
agricultural source (13.46 %). The hazard index (HI) values and carcinogenic risk (CR) for adults are within an acceptable risk level range. The average HI for children is 1.589, which is an unacceptable risk. Source-oriented health risks indicate that metal mining is the main source of health risks due to the large number of arsenic emissions from metallurgical processes. This study identified pollution levels, sources, and risks of HMs and can provide supporting information for effective source regulation.