Calculating pH-solubility profile and pH

• Tác giả: Fady Ibrahim, Fan Meng
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : International journal of pharmaceutics , 2025
• Bộ sưu tập: NCBI
• ID: 710370

Tóm tắt

Pharmaceutical salts are a commonly used strategy to improve the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). The selected salt form is expected to have high solubility to obtain optimal supersaturation and sufficient physical stability for adequate shelf life. In this paper, we aim to develop equations to describe critical parameters of salts, including pH-solubility profile and pH