Spray drying of an oil-in-water emulsion containing vitamin D3: a synergy between formulation and process conditions to obtain microparticles.

• Tác giả: Laura Alessandroni, Alessandro Candiani, Jean Daniel Coïsson, Giada Diana, Andrea Foglio Bonda, Lorella Giovannelli, Andrea Milanesi, Paolo Rassè, Lorena Segale, Alessandro Sodano
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : International journal of pharmaceutics , 2025
• Bộ sưu tập: NCBI
• ID: 710401

Tóm tắt

 Spray drying is a practical solution to convert oil-in-water emulsion into solid microparticles. In this work, a formulation study was conducted to identify the best composition of vitamin D3-loaded oil-in-water emulsion to process via a lab-scale spray dryer. The emulsion was composed of vitamin D3 oily solution (7 % w/w) and maltodextrin (21 % w/w), arabic gum (9 % w/w) and pea protein hydrolysate (1 % w/w) aqueous solution and was characterized by optimal stability (>
  24 h). The spray drying process (T