Antibiotics are of environmental concern. Their concentrations in the aquatic environment are frequently studied, while their occurrence in human excreta-derived fertilizers is less investigated. Therefore, levels of antibiotics, preservatives with antimicrobial properties, and various other micropollutants were determined in sewage sludge and in human fecal compost. Digested sludge of 29 Swiss wastewater treatment plants was analyzed, representing about 2.6 Mio people (30% of the Swiss population). This was compared with residues found in compost with dry toilet content after thermophilic composting, representing about 10 000 people. Fluoroquinolones and preservatives dominate in Swiss sewage sludge with weighted mean concentrations of 6500 μg kg