Modulation of cardiomyocyte contractility and action potentials with chemogenetic chloride currents.

• Tác giả: Torsten Christ, Anita Covic, Thomas Eschenhagen, Junsoo Im, Christoph Manthey, Judith Rössinger, Barbora Schwarzova, Edzard Schwedhelm, Nancy Shehata, Aya Shibamiya, Muhammed Sönmez, Rajiven Srikantharajah, Tim Stüdemann, Florian Weinberger
• Ngôn ngữ: eng
• Thông tin xuất bản: England : The Journal of physiology , 2025
• Bộ sưu tập: NCBI
• ID: 710533

Tóm tắt

Transient perturbation of electrical activity is used in neuroscience to study the impact of specific neuronal cell populations on brain function. Similarly, cardiomyocyte (CM) physiology can be controlled by the activation of artificially expressed ion channels. Pharmacologically selective actuator modules (PSAMs) are engineered ligand-gated ion channels that can be activated with small molecules. We aimed to use the 'inhibitory' PSAMs, (i) PSAM