Increase in the antibiotic's usage and mis-management in antibiotics' disposal has led to the occurrence of antibiotic residues in the surface water bodies. These residues may pose considerable risks to the human as well as aquatic organisms owing to the enhancement in antimicrobial resistance among microbes. Hence, precautionary measures are need of the hour to curtail the occurrence of antibiotic compounds in water. In addition, rampant burning of agricultural waste in India causes considerable air pollution. Considering this, a novel adsorbent has been developed from agricultural waste biomass, viz. wheat straw (WS), through calcination (CWS), followed by chemical activation (AWS). These adsorbents were employed for the removal of ciprofloxacin (CIP) from water. Removal efficiency of 90% (for CWS) and 98% (for AWS) could be achieved at neutral pH in room temperature conditions. The maximum adsorption capacity of ciprofloxacin on synthesized adsorbent was evaluated as 14.51 mg g