A single-cell map of patients with non-small cell lung cancer harboring rare-driver mutations after anti-PD-1 treatment.

• Tác giả: Miao Cai, Rui Fu, Xuan Gao, Ben-Yuan Jiang, Fang Li, Meng-Meng Song, Yi-Long Wu, Xue-Ning Yang, Chao Zhang, Wen-Zhao Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 597.948 *Amphisbaenia (Worm lizards)
• Thông tin xuất bản: Ireland : Cancer letters , 2025
• Bộ sưu tập: NCBI
• ID: 710612

Tóm tắt

The effects of the tumor microenvironment the therapeutic efficacy of combining chemotherapy with checkpoint inhibitors in patients with lung cancer harboring rare -driver mutations remain unclear. We utilized single-cell RNA- and T-cell receptor (TCR) -sequencing to explore the immune and stromal cell profiles of 12 tumors and five tumor-adjacent tissues in seven patients with non-small cell lung cancer (NSCLCs) with rare -driver mutations treated with anti-PD-1 agents combined with chemotherapy. A class of highly expanded T -cells, known as GZMK + CD8