This study is a preliminary assessment of the worst-case scenario of chronic cumulative toxicity of pollutants to marine life in Abu-Qir Bay, Egypt. In addition, human health risks from ingestion, ingestion during swimming, and dermal contact with contaminants were evaluated for children, females and males. Five heavy metals, thirteen polyaromatic hydrocarbons (PAHs), twenty pesticides (OCPs) and five polychlorinated biphenyls (PCBs) were measured in the seawater column and sediments. The average cumulative pollution indices, including the Heavy Metal Pollution Index (HPI: 3.44 ± 0.24) and the Heavy Metal Evaluation Index (HEI: 0.46 ± 0.04), reflected low impacts of heavy metal pollution in seawater, while the Mean Effect Range Medium Quotient (mERMQ: 0.123 ± 0.024) demonstrated low-moderate potential adverse biological effects in sediments. Among PAHs, Benzo[a]pyrene was the most abundant in the seawater (56.0 ng/L). Individual chronic RQ