Facile Synthesis of Ureidic Derivatives of Betulinic Acid With Antiproliferative Effects on Colorectal and Prostate Cancer Cells.

• Tác giả: Henna Amin, Khursheed Ahmad Bhat, Anindya Goswami, Gursimar Kaur
• Ngôn ngữ: eng
• Ký hiệu phân loại: 149.73 Skepticism
• Thông tin xuất bản: Switzerland : Chemistry & biodiversity , 2025
• Bộ sưu tập: NCBI
• ID: 710783

Tóm tắt

Betulinic acid isolated from Platanus orientalis bark was modified in one-pot reaction to furnish 12 ureidic derivatives. The synthesized derivatives were tested against an array of cancer cell lines, colon HCT-116, breast MCF-7, pancreatic MIA PaCa-2, and prostate PC-3 cancer cell lines. Among the synthesized compounds, BA1 exhibited potent anti-cancer activity with IC