BACKGROUND: In the context of global warming, the frequency of heat wave and the concentration of fine particulate matter (PM METHODS: We conducted a time-stratified case-crossover study of 40,169 CVD deaths in Shenzhen, China between 2013 and 2022. Meteorological data and air pollutants information were obtained based on the residential addresses from the validated grid datasets. A total of 21 heat wave definitions were constructed using various relative temperature thresholds and durations. Conditional logistic regression was used to evaluate the independent and interactive effects of exposure to heat wave and PM RESULTS: The odds ratios (ORs) and 95 % confidence intervals (CIs) for CVD mortality associated with heat waves ranged from 1.17 (95 % CI: 1.001,1.36) to 1.91 (95 % CI: 1.42, 2.56). For every increase of 10 µg/m³ in PM CONCLUSIONS: Heat wave and PM