The neutrophil-to-lymphocyte ratio in bronchoalveolar lavage fluid could help to personalize corticosteroid therapy in severe COVID-19 pneumonia.

• Tác giả: Nausicaa Beaudequin, Anne Fajac, Muriel Fartoukh, Benjamin Glemain, Vincent Rothstein, Guillaume Voiriot
• Ngôn ngữ: eng
• Thông tin xuất bản: France : Infectious diseases now , 2025
• Bộ sưu tập: NCBI
• ID: 710907

Tóm tắt

OBJECTIVE: To investigate the response to high-dose corticosteroids according to bronchoalveolar neutrophil-to-lymphocyte ratio (BAL-NLR) in critically-ill COVID-19 patients. METHODS: We retrospectively analyzed a single-center cohort of adult COVID-19 patients admitted to the intensive care unit with COVID-19 pneumonia between 2020 and 2022, who had a bronchoalveolar lavage and received systemic corticosteroids. We defined high-dose corticosteroid therapy as the administration of at least 1mg/kg/day of methylprednisolone. RESULTS: Among 161 patients, 56 had LOW CONCLUSION: Our results suggest that bronchoalveolar cellular phenotype influences therapeutic response to high-dose corticosteroid therapy.