BACKGROUND: Depression impacts nearly 3% of the global adult population. Symptomatology is likely related to regions encompassing frontoparietal, somatosensory, and salience networks. Questions regarding deep brain nuclei (DBN), including the substantia nigra (STN), subthalamic nucleus (STN), and red nucleus (RN) remain unanswered. METHODS: Using an existing structural neuroimaging dataset including 86 individuals (Baranger et al., 2021
n RESULTS: Group differences emerged in deep brain/cortical covariance. Right RN volume covaried with left parietal operculum volume and central sulcus thickness, while left RN and right STN volumes covaried with right occipital pole volume. Positive relationships were observed within the unaffected group and negative relationships among those with depression. These cortical areas did not correlate with HAM-D scores. Simple DBN volumes did not predict diagnostic group. CONCLUSION: Structural codependence between DBN and cortical regions may be important in depression, potentially for sensorimotor features. Future work should focus on causal mechanisms of DBN involvement with sensory integration.