Assessing the therapeutic potential of silicon dioxide nanoparticles in acute and chronic toxoplasmosis in BALB/c mice.

• Tác giả: Ehsan Ahmadpour, Deniz Armanmanesh, Monireh Khordadmehr, Reyhaneh Moghaddami, Ata Moghimi, Kimia Moradi, Ahmad Nematollahi, Parisa Shahbazi, Misagh Yaghubinejad
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Acta tropica , 2025
• Bộ sưu tập: NCBI
• ID: 710957

Tóm tắt

Toxoplasmosis, an infection caused by the obligate intracellular parasite Toxoplasma gondii, represents a significant global health concern, particularly for immunocompromised individuals. This study aimed to evaluate the therapeutic effects of silicon dioxide nanoparticles (SiO2-NPs) against both acute (T. gondii RH strain) and chronic (T. gondii PRU strain) infections in BALB/c mice. In the acute infection model, mice (n = 40) were infected with 10