Salvianolic acid B ameliorates hepatic fibrosis via inhibiting p300/CBP.

• Tác giả: Yongfang Gong, Jiemei Jiang, Lili Li, Miaomiao Li, Yuxuan Li, Wenbo Liu, Hanyang Xu, Yan Yang, Huabiao Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 344.0763 Labor, social service, education, cultural law
• Thông tin xuất bản: Netherlands : European journal of pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 710964

Tóm tắt

Salvianolic acid B (Sal B), an active ingredient extracted from Salvia miltiorrhiza Bunge, has shown hepatic anti-fibrotic activity. Hepatic stellate cells (HSCs) activation is considered the determining event in liver fibrogenesis. E1A binding protein p300 (p300)/CREB binding protein (CBP) is an attractive target for inhibiting HSCs activation. But whether Sal B inhibits hepatic fibrosis through suppressing p300/CBP is unknown. We used DEN/CCl