Are vagal neural crest derived tissues impacted in spliceosomopathies?

• Tác giả: Loydie A Jerome-Majewska, Joshua A Moore
• Ngôn ngữ: eng
• Ký hiệu phân loại: 005.5 General purpose application programs formerly 005.3
• Thông tin xuất bản: England : Differentiation; research in biological diversity , 2025
• Bộ sưu tập: NCBI
• ID: 711007

Tóm tắt

Splicing factors required for mRNA maturation have emerged as important contributors to neural crest development in the craniofacial region. Less is known of the role of these proteins in vagal neural crest cells that contribute to the outflow tract and form the enteric nervous system. In this review, we discuss the current state of our understanding of splicing and potential contribution of mis-splicing to cardiac and ENS defects.