Therapeutic mitochondria treatment amplifies macrophage-mediated phagocytosis and recycling exocytosis.

• Tác giả: Dong Bin Back, Elga Esposito, Kazuhide Hayakawa, Shin Ishikane, Ester Licastro, Yoshihiko Nakamura, Takafumi Nakano, Ji Hyun Park, Giuseppe Pignataro, Masayoshi Tanaka, Fang Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 615.8323 Specific therapies and kinds of therapies
• Thông tin xuất bản: United States : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism , 2025
• Bộ sưu tập: NCBI
• ID: 711091

Tóm tắt

Therapeutic administration of mitochondria has been increasingly explored. However, how these administered mitochondria impact immune response remains to be fully addressed. In this proof-of-concept study, we show that extracellularly added mitochondria to cultured peritoneal macrophages increase phagocytosis and recycling exocytosis that amplifies neuroplasticity mediated by recycled mitochondria transfer. Macrophage activation markers such as