Serratia marcescens (SM) is an opportunistic pathogen associated with outbreaks in immunocompromised hosts. While SM is commonly isolated from clinical and environmental sources, prodigiosin production is typically associated with environmental strains rather than clinical isolates. Here, we report the genome sequences of three pigmented SM clinical isolates -HU1848, HU2225, and HU2228- and examine their genomic and phenotypic characteristics. Phylogenetic analysis using 1103 finished public SM genomes revealed that these isolates cluster more closely with environmental SM strains than with those typically associated with clinical settings. Notably, despite their environmental-like genomic background, these isolates harbor multiple virulence genes implicated in colonization and resistance to fertilizers, as well as antimicrobial resistance genes for chloramphenicol, fosfomycin, and tetracycline. MIC determination showed susceptibility to aminoglycosides and fluoroquinolones. Additionally, we observed that the phenolic compound methyl gallate modulates pigment production and motility. The absence of AHL biosynthetic genes in these pigmented strains challenges previous associations between quorum sensing and prodigiosin biosynthesis. These findings suggest that certain SM strains with environmental-like genetic features can persist in clinical settings, underscoring the need to further investigate their potential role in nosocomial infections.