Diagnosis of Antiphospholipid Syndrome by Chemiluminescent or Enzyme-Linked Immunosorbent Assay - A Comparison Study and Comprehensive Literature Review.

• Tác giả: Stephrene S W Chan, Yen Lin Chee, Eunice E N Lai, Jacqueline P J Lau, Shir Ying Lee, Cheryl X Q Lim, Winnie Z Y Teo, Eng Soo Yap
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis , 2025
• Bộ sưu tập: NCBI
• ID: 711180

Tóm tắt

ObjectiveEnzyme-linked immunosorbent assay (ELISA) is the established method for detecting antiphospholipid antibodies (aPL) in the diagnosis of antiphospholipid syndrome (APS) but is labor-intensive compared with the newer automated chemiluminescent assay (CLIA). This study aims to evaluate CLIA versus ELISA for aPL, correlate each method with clinical manifestations and perform a comprehensive literature review.MethodsPatient samples were concurrently tested by ELISA (QUANTA Lite