HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1.

• Tác giả: John L Bowman, Han-Han Chang, Chiung-Hsiang Cheng, Chao-Tzu Chung, Ru-Ying Fang, Syuan-Fei Hong, Sin-Fen Hu, Yu-Ling Hung, Wann-Neng Jane, Choun-Sea Lin, Pin-Chun Lin, Shih-Shun Lin, Zhao-Jun Pan, Thanh Ha Pham, Qian-Wen Shang, Bing-Nan Shen, Tang-Long Shen, Phuong-Anh Tran, Chia-Chi Wang, Wei-Lun Wei, Fu-Hui Wu, Hsin-Yi Wu, Ju-Ting Yang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 996.9042 North central Pacific islands Hawaii
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 711362

Tóm tắt

Helper-component proteinase (HC-Pro), encoded by potyviruses, function as viral suppressors of RNA silencing (VSRs). Despite their conserved role, HC-Pros share approximately 40% similarity, implying potential differences in VSR efficiency, particularly in their ability to inhibit HEN1 methyltransferase activity. This study investigated the inhibitory potential of HC-Pros from different potyviruses in transgenic plants. P1/HC-Pro from turnip mosaic virus (P1/HC-Pro