Development and validation of a nomogram for predicting postoperative pulmonary complications in older patients undergoing noncardiac thoracic surgery: a prospective, bicentric cohort study.

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Tác giả: Yu Gu, Zhanpeng Huang, Tao Jiang, Dianyu Lu, Feixiang Wang, Haiyan Wang, Wei Wei, Yonghua Yao, Yongxin Zhou

Ngôn ngữ: eng

Ký hiệu phân loại: 635.951 Native habitats

Thông tin xuất bản: England : BMC geriatrics , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 711473

 BACKGROUND: The ARISCAT score, a prospectively developed generic classification for postoperative pulmonary complications (PPCs), has shown excellent predictive performance in general surgery. However, there is no reliable classification instrument for PPCs prediciton in thoracic surgery. OBJECTIVE: This study aimed to develop and validate a novel nomogram for estimating the risk of pulmonary complications in older patients (≥ 65 years) within 30 days after NCTS. METHODS: A nomogram was developed using predefined candidate predictors of 30-day PPCs. It was fitted with least absolute shrinkage and selection operator and logistic regression methods. Internal validation was performed using a bootstrap-resampling approach, while external validation used an independent, temporally separated cohort. The model's performance was assessed based on its discriminative potential (area under the receiver operating characteristic curve [AUC]), predictive ability (calibration plots), and clinical utility (net benefit). RESULTS: In the development (n = 1449) and validation (n = 449) cohorts, 34.9% and 31.4% of patients, respectively, developed pulmonary complications 30 days post-surgery. The final nomogram incorporated eight predictors (age, surgical approach, desaturation of <
  92% for more than 2 min, duration of surgery, smoking status, FEV CONCLUSIONS: This novel nomogram can reliably identify older patients with a high risk for pulmonary complications within 30 days after NCTS. TRIAL REGISTRATION: ChiCTR2100051170.
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