Early-life gut microbiome is associated with behavioral disorders in the Rio birth cohort.

• Tác giả: Carmen Ildes Froes Asmus, Maria Gloria Dominguez-Bello, Armando Meyer, Josino Costa Moreira, Nathalia Ferrazzo Naspolini, Ana Paula Natividade
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.85882 Diseases of nervous system and mental disorders
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 711490

Tóm tắt

 Emerging evidence has been linking changes in the early-life gut microbiome and neurodevelopmental outcomes. The founder bacteria that first colonize the infant's gut determine the microbial succession that signals host tissues and impact development including the brain. Here we investigated the association between the meconium microbiome and neurobehavior. To this end, we surveyed the 16S rRNA gene on meconium samples and assessed behavioral outcomes at six-months of age by the Denver Developmental Screening Test II (DDST-II). Among the four behavioral domains investigated, the personal-social domain was associated with significant differences in meconium bacterial beta diversity (unweighted UniFrac
  R