Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization.

• Tác giả: Deepak Adhikari, John Carroll, Mark A Febbraio, Hilda A Pickett, Sandra G Piltz, Rebecca L Robker, Ryan D Rose, Darryl L Russell, Alexander P Sobinoff, Hazel H Szeto, Paul Q Thomas, Jadon K Wells, Yasmyn E Winstanley, Lee H Wong, Linda L Wu, Qing-Hua Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 968.8702 *Namibia, Botswana, Lesotho, Swaziland
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 712019

Tóm tắt

 The initial setting of telomere length during early life in each individual has a major influence on lifetime risk of aging-associated diseases
  however there is limited knowledge of biological signals that regulate inheritance of telomere length, and whether it is modifiable is not known. We now show that when mitochondrial activity is disrupted in mouse zygotes, via exposure to 20% O