FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice.

• Tác giả: Alexandra Abromeit, Markus Ballmann, Joeri Bordes, Michael Czisch, Jan M Deussing, Matthias Eder, Daniela Harbich, Rosa-Eva Huettl, Janine Knauer-Arloth, Juan Pablo Lopez, Danusa Menegaz, Shiladitya Mitra, Sowmya Narayan, Gerhard Rammes, Ghalia Rehawi, Mathias V Schmidt, Tibor Stark, Lotte van Doeselaar, Huanqing Yang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 780 Music
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 712055

Tóm tắt

Early life stress (ELS) can increase vulnerability to psychiatric disorders, but also trigger resilience. FKBP51 has been associated with an increased risk for developing psychiatric disorders, specifically in interaction with ELS exposure. Here, the contribution of FKBP51 in glutamatergic forebrain neurons to the long-term consequences of ELS was investigated in both sexes. In female wild-type Fkbp5