Overexpression of miR-99a promoted expansion and suppressed differentiation of hematopoietic stem/progenitor cells.

• Tác giả: Ting Chen, Xing Hao, Yihan Li, Xue Lv, Jun Shi, Xiaohui Si, Wenjun Wang, Wen Xing, Yuan Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 712164

Tóm tắt

MicroRNAs (miRNAs) are a class of non-coding RNAs involved in a variety of pathophysiological processes. We have previously reported that the abnormally high expression of miR-99a is associated with drug resistance and poor prognosis in acute myeloid leukemia. However, the impact of miR-99a on normal hematopoiesis is not well understood. To investigate the effect of aberrant miR-99a overexpression on hematopoietic stem and progenitor cells (HSPCs), we overexpressed miR-99a in human umbilical cord blood CD34