Proteogenomic characterization of molecular and cellular targets for treatment-resistant subtypes in locally advanced cervical cancers.

• Tác giả: Seunghoon Back, Jingi Bae, Young-Ki Bae, Hye Jung Baek, Soo Young Cho, Wonyoung Choi, Eun-Kyung Hong, Daehee Hwang, Do Young Hyeon, Juhee Jeong, Eunsoo Jung, Keehoon Jung, Chaewon Kang, Jihyung Kang, Duk Ki Kim, Hokeun Kim, Jong Kwang Kim, Joo-Young Kim, Sang Soo Kim, Suhwan Kim, Su-Jin Kim, Ja-Lok Ku, Sang-Jin Lee, Sang-Won Lee, Myong Cheol Lim, Inamul Hasan Madar, Dowoon Nam, Geon Woo Park, Ki Seok Park, Dong Hoon Shin, Hye-Jin Shin, Yourae Shin, Chong Woo Yoo
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: England : Molecular cancer , 2025
• Bộ sưu tập: NCBI
• ID: 712564

Tóm tắt

We report proteogenomic analysis of locally advanced cervical cancer (LACC). Exome-seq data revealed predominant alterations of keratinization-TP53 regulation and O-glycosylation-TP53 regulation axes in squamous and adeno-LACC, respectively, compared to in early-stage cervical cancer. Integrated clustering of mRNA, protein, and phosphorylation data identified six subtypes (Sub1-6) of LACC among which Sub3, 5, and 6 showed the treatment-resistant nature with poor local recurrence-free survival. Elevated immune and extracellular matrix (ECM) activation mediated by activated stroma (PDGFD and CXCL1