Replacement of phenyl substituents at phosphorus by hexyl ones in 2-(2-hydroxyaryl)vinylphosphonium salts can tune the nature of the induced proton transport through lipid membranes.

• Tác giả: Yuri N Antonenko, Ljudmila S Khailova, Elena A Kotova, Vladimir F Mironov, Tatyana I Rokitskaya, Anna G Strelnik, Dmitry A Tatarinov
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Biochimica et biophysica acta. Biomembranes , 2025
• Bộ sưu tập: NCBI
• ID: 712690

Tóm tắt

2-(2-hydroxyaryl)vinylphosphonium salts are zwitterionic protonophores previously shown to induce proton transport across lipid membranes via cyclic deprotonation and protonation of the hydroxyl group. Here, we examine the impact of the kind of substituents at phosphorus on the protonophoric activity of these compounds. In particular, replacement of all the three phenyl groups at the phosphorus atom of the 2-(2-hydroxyaryl)vinyl(triphenyl)phosphonium salt (2HVPPh