Copy number variation at the complement C4 locus is associated with risk for multiple sclerosis.

• Tác giả: Danillo G Augusto, Stacy Caillier, Jill A Hollenbach, Kerry Kizer, Wesley M Marin, Paul J Norman, Rayo Suseno, Kristen J Wade, Jacqueline Williams
• Ngôn ngữ: eng
• Ký hiệu phân loại: 623.4511 Ordnance
• Thông tin xuất bản: England : Multiple sclerosis (Houndmills, Basingstoke, England) , 2025
• Bộ sưu tập: NCBI
• ID: 712763

Tóm tắt

BACKGROUND: The complement system has been suspected to play a role in multiple sclerosis (MS) due to presence of complement activation products in MS lesions. OBJECTIVE: We sought to understand whether variation in the complement component 4 (C4) gene is associated with MS. METHODS: Here we used next-generation sequencing and our novel bioinformatics tool, RESULTS: We found higher overall copy number of C4 in controls ( CONCLUSION: This finding suggests that lower C4 copies confer risk for MS, similar to associations seen in other autoimmune disorders.